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Matrixyl Synthe 6® explained

Ageing is inevitable and a fact of life. Skin ageing is caused by two distinct processes: intrinsic and extrinsic ageing.

Intrinsic Ageing – natural cellular and biological functions slow. Over time, the skin’s strong, collagen and elastic matrix begins to weaken, slowing down skin cell turnover and contributing to hyaluronic acid, elastin and collagen depletion. As these essential materials diminish, the skin loses strength and resilience.

Example – Collagen, the protein that forms a matrix in between the skin’s layers and helps it look taut and plump, starts to break down.

Extrinsic Ageing – is caused by a set of external factors that accelerate the ageing process, including lifestyle choices like smoking, alcohol consumption and lack of exercise, as well as environmental stressors like pollution, blue light radiation and UV exposure. Exposes the skin to free radicals and oxidative stress which damage its structural proteins and causing it to age prematurely.

Example – years of sun exposure can lead to dark spots that no longer disappear (hyperpigmentation, darker spots on the skin, can also occur after an acne breakout)

Matrixyl Synthe 6® can help in making your skin look its best and enhance its glow by improving its radiance and luminosity through the strengthening of the skins natural barriers and defences.

A powerful high-tech peptide that encourages the production of six skin-rebuilding essentials. Matrixyl Synthe 6® is a deoxygenated lipopeptide that stimulates the synthesis of 6 major ingredients in the skin’s matrix and dermal-epidermal junction.

  1. Collagen I: the main part of the deeper skin layers
  2. Collagen III
  3. Collagen IV: collagens produced for wound-healing
  4. Fibronectin: assists in tissue repair
  5. Hyaluronic acid: improves skin elasticity
  6. Laminin-5: anchors the skin’s layers


Firms: Stimulates collagen synthesis of type by 105%, type III by 104% and type IV by 42% when applied twice daily at 2% concentrations for 60 days – decreasing wrinkle volume by 31% of the forehead and wrinkle surface by 28.5% of the eyes.

Lifts: Diminishes sagging by 28% when applied twice daily at 2% concentration within 60 days.

Plumps: Boosts Hyaluronic Acid synthesis up to 174%, improving skin hydration, elasticity and moisture.

Smooths: Improves Laminin-5 production by 75%, an adhesion glycoprotein that helps to anchor the epidermis to the dermis.

Repairs: Increases Fibronectin A levels accelerating repair within the Extra Cellular Matrix (ECM).


Research and studies show that Matrixyl Synthe 6® can nearly double the amount of collagen that our bodies produce. Sederma found that 2% Matrixyl Synthe 6® applied twice daily for five days increased type I collagen by 105%, type III collagen by 104% and type IV collagen by 42%.

Inspira Cosmetics products that contain Matrixyl Synthe 6®:






Ingredient Spotlight Matrixyl Synthe’6 – Skin Care Advice, Trends: December 3, 2019 –

Skin Ageing The Causes – How The Environment Ages Your Skin, August 12, 2019 –

Focus: Matrixyl (3000 & synthe’6) July 18, 2019 – /

The Fall Of “Anti-Aging” Skin Care – September 2018 –